abstract：:Exposure to sunlight is a major source of vitamin D for most people. Yet public health advice has focused overwhelmingly on avoiding exposure of unprotected skin because of the risks of erythema and skin cancer. Given that there are also health risks associated with low vitamin D status, we explore the possibilities o...

journal_title：Advances in experimental medicine and biology

authors： Webb AR,Engelsen O

更新日期：2020-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) infect squamous epithelia and can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. While mucosal high-risk HPVs have a well-established causal role in anogenital carcinogenesis, the biology of cutaneous...

journal_title：Advances in experimental medicine and biology

authors： Smola S

更新日期：2020-01-01 00:00:00

abstract：:Gremlin is a member of the TGF-β superfamily that can act as a BMP antagonist, and recently, has been described as a ligand of the vascular endothelial growth factor receptor 2 (VEGFR2). Gremlin shares properties with the Notch signaling pathway. Both participate in embryonic development and are reactivated in patholo...

journal_title：Advances in experimental medicine and biology

authors： Marquez-Exposito L,Cantero-Navarro E,R Rodrigues-Diez R,Orejudo M,Tejera-Muñoz A,Tejedor L,Rayego-Mateos S,Rández-Carbayo J,Santos-Sanchez L,Mezzano S,Lavoz C,Ruiz-Ortega M

更新日期：2020-01-01 00:00:00

abstract：:Humoral immunity provides protection from pathogen infection, and this is mediated by antibodies that are produced by plasma cells. Plasma cells are terminally differentiated from activated B cells and are specialized for secreting antibodies. Plasma cells are generated during extrafollicular or germinal center (GC) r...

journal_title：Advances in experimental medicine and biology

authors： Ise W,Kurosaki T

更新日期：2020-01-01 00:00:00

abstract：:Stem cells provide for all of the tissues in our body during embryogenesis. In adult organisms, they can be found as rare populations of tissue-specific stem cells in quiescent states, although they can still regenerate damaged tissues. Astonishingly, these cells are retained in tissues even post-mortem. There have be...

journal_title：Advances in experimental medicine and biology

authors： Haring G,Zupan J

更新日期：2020-01-01 00:00:00

abstract：:Gut microbiota are known to impact multiple organs including the lung. The cross talk between gut microbes and lungs, termed as the "gut-lung axis," is vital for immune response and homeostasis in the airways. In this chapter, we summarized the coordinated development of microorganisms in the gut and lung, exogenous a...

journal_title：Advances in experimental medicine and biology

authors： Tan JY,Tang YC,Huang J

更新日期：2020-01-01 00:00:00

abstract：:Seasonality of respiratory syncytial virus (RSV) infection is an area of limited knowledge. In this study, we set out to get insight into the epidemic characteristics of RSV. We retrospectively evaluated medical files of 512 hospitalizations in children due to RSV infection from January 2010 to July 2017. In this coho...

journal_title：Advances in experimental medicine and biology

authors： Wrotek A,Czajkowska M,Jackowska T

更新日期：2020-01-01 00:00:00

abstract：:Stem cell-based therapy has shown exciting efficacy in pre-clinical studies on different neurodegenerative diseases (NDs). However, no clinically applicable stem-cell-derived neurons are available to the patients with NDs. There exist some obstacles associated with stem cell therapy, which need to be overcome in futur...

journal_title：Advances in experimental medicine and biology

authors： Han F,Lu P

更新日期：2020-01-01 00:00:00

abstract：:Skin is the main organ that covers the human body and acts as a protective barrier between the human body and the environment. Skin tissue as a stem cell source can be used for transplantation in therapeutic application in terms of its properties such as abundant, easy to access, high plasticity and high ability to re...

journal_title：Advances in experimental medicine and biology

authors： Çankirili NK,Altundag O,Çelebi-Saltik B

更新日期：2020-01-01 00:00:00

abstract：:In this study, we explored the effect of three lactic acid bacteria (LAB), i.e. Enterococcus sp CM9, Enterococcus sp CM18 and Enterococcus faecium H3, and their supernatants, on seven biofilm-forming pathogenic strains isolated from human urinary tract or nose infections. By quantitative biofilm production assay, a st...

journal_title：Advances in experimental medicine and biology

authors： Benmouna Z,Dalache F,Zadi-Karam H,Karam NE,Vuotto C

更新日期：2020-01-01 00:00:00

abstract：:Among the pathological alterations that give tumor cells invasive potential, purinergic signaling is emerging as an important component. Studies performed in in vitro, in vivo and ex vivo glioma models indicate that alterations in the purinergic signaling are involved in the progression of these tumors. Gliomas have l...

journal_title：Advances in experimental medicine and biology

authors： Braganhol E,Wink MR,Lenz G,Battastini AMO

更新日期：2020-01-01 00:00:00

abstract：:Checkpoint inhibitors are part of the family of immunotherapies and are increasingly being used in a wide variety of cancers. Immune-related adverse events pose a major challenge in the treatment of cancer patients. Pneumonitis is a rare immune-related adverse event that presents in distinct patterns. The goal of this...

journal_title：Advances in experimental medicine and biology

authors： Zhong L,Altan M,Shannon VR,Sheshadri A

更新日期：2020-01-01 00:00:00

abstract：:While melanoma is less common than some other skin cancers, it is responsible for nearly 10,000 deaths in the USA each year alone. For many decades, very limited treatment options were available for patients with metastatic melanoma. However, recent breakthroughs have brought new hopes for patients and providers. Whil...

journal_title：Advances in experimental medicine and biology

authors： Albittar AA,Alhalabi O,Glitza Oliva IC

更新日期：2020-01-01 00:00:00

abstract：:Testicular germ cell tumors (TGCTs) represent the most common neoplasia among young men. Management of TGCTs is an excellent example of curative outcomes in clinical oncology. The unique sensitivity to cisplatin-based chemotherapy regimens has led to establishing TGCTs as a "model of cancer cure." However, mechanisms ...

journal_title：Advances in experimental medicine and biology

authors： Kalavska K,Kucerova L,Schmidtova S,Chovanec M,Mego M

更新日期：2020-01-01 00:00:00

abstract：:It is well established that palmitoylation plays a key role in the regulation of immune checkpoints, but the technical challenges in detecting protein palmitoylation have significantly prohibited further researches in this field. Till now, different approaches have been proposed, such as mutagenesis, antibody-based me...

journal_title：Advances in experimental medicine and biology

authors： Lu H,Fang C

更新日期：2020-01-01 00:00:00

abstract：:Advancements in musculoskeletal analysis have been achieved by adopting deep learning technology in image recognition and analysis. Unlike musculoskeletal modeling based on computational anatomy, deep learning-based methods can obtain muscle information automatically. Through analysis of image features, both approache...

journal_title：Advances in experimental medicine and biology

authors： Kamiya N

更新日期：2020-01-01 00:00:00

abstract：:Immunotherapy with checkpoint inhibitor has been successfully applied in treatment for multiple cancer types, especially for patients at advanced stage. However, response rate of this promising therapy is low, thus requiring biomarkers for precise medication to reduce the ineffective treatment. With multiple retrospec...

journal_title：Advances in experimental medicine and biology

authors： Hou Q,Xu H

更新日期：2020-01-01 00:00:00

abstract：:Deep learning is the state-of-the-art machine learning approach. The success of deep learning in many pattern recognition applications has brought excitement and high expectations that deep learning, or artificial intelligence (AI), can bring revolutionary changes in health care. Early studies of deep learning applied...

journal_title：Advances in experimental medicine and biology

authors： Chan HP,Samala RK,Hadjiiski LM,Zhou C

更新日期：2020-01-01 00:00:00

abstract：:The tumor microenvironment is composed of cancer cells, noncancer cells (e.g., immune cells, stromal cells, endothelial cells, and adipocytes), and various mediators (e.g., cytokines, chemokines, growth factors, and humoral factors) that work together to support cancer growth, progression, and resistance to therapies....

journal_title：Advances in experimental medicine and biology

authors： Kang R,Zeh H,Lotze M,Tang D

更新日期：2020-01-01 00:00:00

abstract：:The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family found in a variety of tissues and is expressed in the stroma of various forms of cancer. Decorin has gained rec...

journal_title：Advances in experimental medicine and biology

authors： Baghy K,Reszegi A,Tátrai P,Kovalszky I

更新日期：2020-01-01 00:00:00

abstract：:Clinical application of induced pluripotent stem cells (iPSCs), which can be differentiated into a wide variety of functional cells, is underway and some clinical trials have already been performed or are ongoing. On the other hand, the risk of carcinogenesis is an issue and the mechanism of cellular reprograming rema...

journal_title：Advances in experimental medicine and biology

authors： Nakamura Y,Shimizu Y

更新日期：2020-01-01 00:00:00

abstract：:Smoking is a harmful habit, causing a range of severe consequences which could lead to premature death. This habit is still prevalent amongst young people. In order to protect children, effective early interventions supported by public instances need to be set in place. Raising awareness and educating the youth is cru...

journal_title：Advances in experimental medicine and biology

authors： Borovanska Z,Poyade M,Rea PM,Buksh ID

更新日期：2020-01-01 00:00:00

abstract：:Rare diseases are gathering increasing attention in last few years, not only for its effects on innovation scientific research, but also for its propounding influence on common diseases. One of the most famous milestones made by Michael Brown and Joseph Goldstein in metabolism field is the discovery of the defective g...

journal_title：Advances in experimental medicine and biology

authors： Zhou H,Gong Y,Wu Q,Ye X,Yu B,Lu C,Jiang W,Ye J,Fu Z

更新日期：2020-01-01 00:00:00

abstract：:PLTP plays an important role in lipoprotein metabolism and cardiovascular disease development in humans; however, the mechanisms are still not completely understood. In mouse models, PLTP deficiency reduces cardiovascular disease, while its overexpression induces it. Therefore, we used mouse models to investigate the ...

journal_title：Advances in experimental medicine and biology

authors： Jiang XC

更新日期：2020-01-01 00:00:00

abstract：:Peroxisomopathies are rare diseases due to dysfunctions of the peroxisome in which this organelle is either absent or with impaired activities. These diseases, at the exception of type I hyperoxaluria and acatalasaemia, affect the central and peripheral nervous system. Due to the significant impact of peroxisomal abno...

journal_title：Advances in experimental medicine and biology

authors： Zarrouk A,Nury T,El Hajj HI,Gondcaille C,Andreoletti P,Moreau T,Cherkaoui-Malki M,Berger J,Hammami M,Lizard G,Vejux A

更新日期：2020-01-01 00:00:00

abstract：:Storyboards are a series of thumbnail images that act as a planning document for your overall animation project. Each thumbnail image is part of what is known as a shot, and shots are strung together to create scenes, which in turn create a whole animation. Medical animations, compared to film or animated movies, have...

journal_title：Advances in experimental medicine and biology

authors： Okemow SJ

更新日期：2020-01-01 00:00:00

abstract：:The availability of numerical data grows from 1 day to another in a remarkable way. New technologies of high-throughput Next-Generation Sequencing (NGS) are producing DNA sequences. Next-Generation Sequencing describes a DNA sequencing technology which has revolutionized genomic research. In this paper, we perform som...

journal_title：Advances in experimental medicine and biology

authors： Kanavos A,Livieris I,Mylonas P,Sioutas S,Vonitsanos G

更新日期：2020-01-01 00:00:00

abstract：:This paper describes a comprehensive application with three features to diagnose common and rare diseases and to optimize health and vitality of the user with the help of broad databases and state-of-the-art technologies. The features comprise: 1. A digital blood analysis for optimizing the patient's metabolism and he...

journal_title：Advances in experimental medicine and biology

authors： Singh P

更新日期：2020-01-01 00:00:00

abstract：:Olive oil is a key ingredient in the Mediterranean diet and offers many health benefits. However, many factors affect the quality and quantity of olive oil such as olive tree diseases and olive-related pests. Unfortunately, the procedure of identifying pests or the outbreak of a disease is time-consuming, and it depen...

journal_title：Advances in experimental medicine and biology

authors： Vlachos I,Kalamatianos R,Karydis I,Spiridonidou A,Avlonitis M

更新日期：2020-01-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is an established clinical technique that measures diffusion-weighted signals, applied primarily in brain studies. Diffusion tensor imaging (DTI) is a technique that uses the diffusion-weighted signals to obtain information about tissue connectivity, which recently started to become es...

journal_title：Advances in experimental medicine and biology

authors： Delibasis Κ,Aronis C,Fanariotis M,Maglogiannis I

更新日期：2020-01-01 00:00:00

abstract：:Decellularized organs and tissues are effectively utilized in a diversity of regenerative medicine purposes, and the decellularization approaches employed differ as broadly as the tissues/organs of concern. Biological scaffold substances formed by extracellular matrix (ECM) are mostly produced with methods that includ...

journal_title：Advances in experimental medicine and biology

authors： Somuncu ÖS

更新日期：2020-01-01 00:00:00

abstract：:Mobile health applications are steadily gaining momentum in the modern world given the omnipresence of various mobile or Wi-Fi connections. Given that the bandwidth of these connections increases over time, especially in conjunction with advanced modulation and error-correction codes, whereas the latency drops, the co...

journal_title：Advances in experimental medicine and biology

authors： Drakopoulos G,Mylonas P,Sioutas S

更新日期：2020-01-01 00:00:00

abstract：:Vascular dementia (VaD) is well recognized as the second most familiar form of dementia in the aged population. The present study is aimed to investigate the neuroprotective effects of ethanolic extract of leaves of Ocimum sanctum (EEOS) against hyperhomocysteinemia (HHcy)-induced vascular dementia (VaD) in Wistar rat...

journal_title：Advances in experimental medicine and biology

authors： Pasangulapati JP,Ravula AR,Kanala DR,Boyina S,Gangarapu K,Boyina HK

更新日期：2020-01-01 00:00:00

abstract：:Drug addiction is a chronic relapsing disorder and a burden to society and individuals. The toxicity induced by drugs related with addiction may trigger dysfunction and death of cells of the central nervous system. The study of alterations of proteins and biomarkers in buccal cells would be beneficial in understanding...

journal_title：Advances in experimental medicine and biology

authors： Gonidi M,Tselenti A,Plerou A

更新日期：2020-01-01 00:00:00

abstract：:Herein, we deploy an in silico pipeline of structural bioinformatics, thermodynamics, and molecular dynamics to investigate the role of cortisol in circadian rhythms, biorhythms, stress response, and even sleep disorders. Our study shows that high concentrations of cortisol intercalate in the minor groove of DNA. This...

journal_title：Advances in experimental medicine and biology

authors： Raftopoulou S,Nicolaides NC,Papageorgiou L,Amfilochiou A,Zakinthinos SG,George P,Eliopoulos E,Chrousos GP,Vlachakis D

更新日期：2020-01-01 00:00:00

abstract：:Personalized medicine has been driven by improvements in genomic sequencing and analysis. For several diseases, in particular cancers, it has for nearly a decade been standard clinical practice to analyze the genome and expression of the genes of patients. The results are reflected directly in the treatment plan for t...

journal_title：Advances in experimental medicine and biology

authors： Bagger FO,Probst V

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cognitive screening measures are widely administered in everyday clinical practice in different geriatric settings. Despite the presence of several extended-like screening tests, Mini-Mental State Examination (MMSE) continues to be largely used not only by neuropsychologists, neurologists, and psychiatrists ...

journal_title：Advances in experimental medicine and biology

authors： Mougias A,Christidi F,Kaldi M,Kerossi MI,Athanasouli P,Politis A

更新日期：2020-01-01 00:00:00

abstract：:This chapter overviews roles of DNA methylation in inflammatory cell biology with the focuses on lymphocytes and macrophages/monocytes in lung diseases, although the molecular mechanisms by which target genes are methylated and regulated in lung diseases remain unclear. Most of epigenetic studies on DNA methylation of...

journal_title：Advances in experimental medicine and biology

authors： Liu Y,Gao H,Wang X,Zeng Y

更新日期：2020-01-01 00:00:00

abstract：:Necrotizing soft tissue infections (NSTI) are multifactorial and characterized by dysfunctional, time dependent, highly varying hyper- to hypo-inflammatory host responses contributing to disease severity. Furthermore, host-pathogen interactions are diverse and difficult to identify and characterize, due to the many di...

journal_title：Advances in experimental medicine and biology

authors： Martins Dos Santos VAP,Hardt C,Skrede S,Saccenti E

更新日期：2020-01-01 00:00:00

abstract：:All who have contributed in writing this chapter have been patients and parents that have experienced an horrific life event. The horrific disease named necrotising fasciitis has affected our lives for ever. All four stories have explained how easily an everyday infection can develop incredibly quickly into a life-thr...

journal_title：Advances in experimental medicine and biology

authors： Cartledge D,Dove L,Richardson E,Wilkie R

更新日期：2020-01-01 00:00:00